Wesley Combs
AI Transformation Leader & Futurist
Product • Engineering • Entrepreneurship • Strategy
Equal parts product leader, engineer, entrepreneur, and business strategist. 25+ years driving AI transformation across healthcare, finance, supply chain, and eCommerce. Led NextGen Healthcare to ship the first Ambient AI on mobile EHR. Currently building production AI systems using multi-model LLM pipelines and agentic workflows. Track record includes $180M+ in Medicare savings, $320M product portfolio leadership, 50+ person technology organizations, and 10 consecutive years of positive ACO performance. I help organizations transform complex workflows with AI that actually ships.
Experience
Founder & CEOCurrent
Phiniti.ai / Ambient Scribe
Building AI-powered clinical documentation platform with architecture provisioned for CDS Hooks and real-time decision support.
- •Multi-model LLM pipelines using AWS Bedrock, OpenAI, Claude, and Claude Agent SDK
- •Full-stack development: iOS (SwiftUI), Android (Jetpack Compose), Web (Next.js/TypeScript)
- •Serverless infrastructure design with infrastructure as code
- •FHIR R4 integration via Medplum for EHR data exchange
- •Beta Tech Accelerator 2025 selection
Stack: AWS Bedrock, OpenAI, Claude, Serverless, IaC, SwiftUI, Jetpack Compose, TypeScript, FHIR
VP, Clinical Solutions
NextGen Healthcare
Led AI-first clinical strategy for $1.8B enterprise (acquired by Thoma Bravo).
- •Shipped first Ambient AI on mobile EHR (November 2023), an industry first
- •Led $320M clinical product portfolio across EHR, Mobile, and clinical content
- •Architected CDS Hooks platform with $182M revenue opportunity
- •Designed FHIR-based strangler fig architecture for legacy modernization
- •Managed cross-functional teams across engineering, product, and data science
Chief Information Officer
State of Franklin Healthcare Associates
Built IT infrastructure for 2,000-physician ESOP medical group during rapid expansion.
- •Secured $4M infrastructure modernization approval from board
- •Led 1 clinic/month acquisition cadence with data migration and integration
- •Built self-service analytics platform with value-based care dashboards
- •Architected data pipelines for clinical, claims, and operational data
CIO & President
Holston Medical Group / OnePartner / ACO Leadership
Built and led healthcare data platforms generating $180M+ in Medicare savings.
- •Led 50+ person technology organization; built team now leading at Cerner, Optum, PointClickCare
- •Architected HIE platform serving 3M+ lives across 9 states with 5x ROI
- •10 consecutive years of positive ACO performance ($76M+ earned savings)
- •Built data pipelines processing ADT, claims, and clinical data from 100+ practices
- •Negotiated national Allscripts reseller partnership, expanding to new markets
Founder & CEO
Lucent Glow, Inc
Healthcare IT pioneer during formative era of health information exchange.
- •Participated in NHIN1/NHIN2 pilots under David Brailer (first National Health IT Coordinator)
- •Built HL7/CCD data interfaces for healthcare interoperability
- •Grew from sole proprietor to 10 employees
- •Successfully exited via sale in 2011
Technical Expertise
AI/ML
Healthcare
Cloud & DevOps
Development
EHR Experience
Education
Executive MBA, Healthcare Leadership
Haslam College of Business, University of Tennessee
2019
B.S. Computer Science
East Tennessee State University
2001
Recognition
Available for AI transformation consulting, fractional leadership, and advisory roles.