Wesley Combs
AI Transformation Leader & Futurist
Product • Engineering • Entrepreneurship • Strategy
Equal parts product leader, engineer, entrepreneur, and business strategist. 25+ years driving AI transformation across healthcare, finance, supply chain, and eCommerce. Led NextGen Healthcare to ship the first Ambient AI on mobile EHR. Currently building production AI systems using multi-model LLM pipelines and agentic workflows. Track record includes $76M+ in earned shared savings across two Medicare ACOs, $320M product portfolio leadership, 50+ person technology organizations, and 10 consecutive years of positive ACO performance. I help organizations transform complex workflows with AI that actually ships.
Experience
Founder & Chief ArchitectCurrent
Phiniti.ai / Ambient Scribe
Building AI-powered clinical documentation platform with architecture provisioned for CDS Hooks and real-time decision support.
- •Multi-model LLM pipelines using AWS Bedrock, OpenAI, Claude, and Claude Agent SDK
- •Full-stack development: iOS (SwiftUI), Android (Jetpack Compose), Web (Next.js/TypeScript)
- •Serverless infrastructure design with infrastructure as code
- •FHIR R4 integration via Medplum for EHR data exchange
- •HIPAA-compliant voice agents handling live clinic phone traffic with warm human escalation
Stack: AWS Bedrock, OpenAI, Claude, Serverless, IaC, SwiftUI, Jetpack Compose, TypeScript, FHIR
Chief Information Officer
State of Franklin Healthcare Associates
Built the technology organization for a 280-provider, 38-practice ESOP medical group targeting growth to 2,000 providers.
- •Secured $4M infrastructure modernization approval from board
- •Led 1 clinic/month acquisition cadence with data migration and integration
- •Built self-service analytics platform with value-based care dashboards
- •Architected data pipelines for clinical, claims, and operational data
VP, Clinical Solutions
NextGen Healthcare
Led AI-first clinical strategy for $1.8B enterprise (acquired by Thoma Bravo).
- •Shipped first Ambient AI on mobile EHR (November 2023), an industry first
- •Led $320M clinical product portfolio across EHR, Mobile, and clinical content
- •Architected CDS Hooks platform with $182M revenue opportunity
- •Designed FHIR-based strangler fig architecture for legacy modernization
- •Managed cross-functional teams across engineering, product, and data science
CIO & President
Holston Medical Group / OnePartner / ACO Leadership
Built and led the healthcare data platforms behind two Medicare ACOs and a nine-state health information exchange.
- •Led 50+ person technology organization; built team now leading at Cerner, Optum, PointClickCare
- •Architected HIE platform serving 3M+ lives across 9 states with 5x ROI; OnePartner has since been acquired by Optum
- •10 consecutive years of positive ACO performance ($76M+ in earned shared savings)
- •Built data pipelines processing ADT, claims, and clinical data from 100+ practices
- •Negotiated national Allscripts reseller partnership, expanding to new markets
Founder & CEO
Lucent Glow, Inc
Healthcare IT pioneer during formative era of health information exchange.
- •Participated in NHIN1/NHIN2 pilots under David Brailer (first National Health IT Coordinator)
- •Built HL7/CCD data interfaces for healthcare interoperability
- •Grew from sole proprietor to 10 employees
- •Successfully exited via sale in 2011
Applications Specialist II
Wellmont Health System / MEDex
Entry into healthcare technology on the hospital floor, building the interface work that became a career.
- •HL7 interfaces on Cloverleaf and eGate for lab and clinical integration
- •Claims processing, transcription, patient indexing, and critical care monitoring
- •Authored and sold Ultimate HL7 for .NET, a commercial parsing tool, across several hundred licenses
- •System administration and scripting across AIX, DGUX, and Windows
IT Consultant
Enhanced Systems Consulting
Client delivery while finishing school, working across eCommerce, banking, and municipal systems.
- •Converted Wideners.com from a FoxPro catalog to SQL Server and Classic ASP e-commerce in 30 to 45 days
- •Moved roughly $1M, about 30% of mail order and call center volume, online in the first year
- •Early loan application workflows against AS/400 financials
- •Content management system used by banks and medical groups
Technical Expertise
AI/ML
Healthcare
Cloud & DevOps
Development
EHR Experience
Education
Executive MBA, Healthcare Leadership
Haslam College of Business, University of Tennessee
2019
B.S. Computer Science
East Tennessee State University
2001